Sale Hospital is the largest hospital campus within Central Gippsland Health. It has a 24-hour emergency department, operating theatres, Critical Care Unit, Level 2 Special Care Nursery, maternity services, paediatrics, dialysis, oncology, and general medical and surgical wards.

Community Care administration offices are located here, as is Wilson Lodge Nursing Home and the Community Rehabilitation Centre.

The main hospital entrance is located on Guthridge Parade.